facebook
twitter
rss
account
search
search
 

Next generation smallpox vaccine in trials

March 21, 2005 at 6:49 PM   |   Comments

BALTIMORE, March 21 (UPI) -- Interim data from a phase I/II U.S. clinical trial of a next-generation vaccine for smallpox suggest the vaccine provides immunity without adverse events.

LC16m8 is a live attenuated smallpox vaccine that is produced in cell culture from vaccinia virus that has been attenuated, or modified, so that it can initiate an immune response without causing serious adverse effects. It has been licensed in Japan since 1980.

"The preliminary study results are consistent with the far larger Japanese experience," Dr. Richard Greenberg of the Kentucky School of Medicine, told the 2005 American Society for Microbiology Biodefense Research Meeting. "LC16m8, an attenuated smallpox vaccine, has had a 100 percent take rate and has been well tolerated -- intensive monitoring for myopericarditis has not uncovered any cardiac toxicity in the first 66 volunteers."

"Take rate" is a measure of a smallpox vaccine's effectiveness in producing an immune response.

The only smallpox vaccine licensed for use in the United States is made from unattenuated vaccinia virus and it has been associated with potentially fatal encephalitis and heart inflammation.

© 2005 United Press International, Inc. All Rights Reserved. Any reproduction, republication, redistribution and/or modification of any UPI content is expressly prohibited without UPI's prior written consent.
Most Popular
1
Wisconsin shuts down three wolf hunting zones, two remain open Wisconsin shuts down three wolf hunting zones, two remain open
2
Harvard scientist startled by giant bird-eating spider on rainforest walk Harvard scientist startled by giant bird-eating spider on rainforest walk
3
Earth's magnetic field may soon flip, according to new data Earth's magnetic field may soon flip, according to new data
4
Peaking Orionid meteor shower to be obscured by nor'easter Peaking Orionid meteor shower to be obscured by nor'easter
5
Soda drinkers may be slowly killing themselves Soda drinkers may be slowly killing themselves
Trending News
Around the Web
x
Feedback