facebook
twitter
rss
account
search
search
 

Next generation smallpox vaccine in trials

March 21, 2005 at 6:49 PM   |   Comments

BALTIMORE, March 21 (UPI) -- Interim data from a phase I/II U.S. clinical trial of a next-generation vaccine for smallpox suggest the vaccine provides immunity without adverse events.

LC16m8 is a live attenuated smallpox vaccine that is produced in cell culture from vaccinia virus that has been attenuated, or modified, so that it can initiate an immune response without causing serious adverse effects. It has been licensed in Japan since 1980.

"The preliminary study results are consistent with the far larger Japanese experience," Dr. Richard Greenberg of the Kentucky School of Medicine, told the 2005 American Society for Microbiology Biodefense Research Meeting. "LC16m8, an attenuated smallpox vaccine, has had a 100 percent take rate and has been well tolerated -- intensive monitoring for myopericarditis has not uncovered any cardiac toxicity in the first 66 volunteers."

"Take rate" is a measure of a smallpox vaccine's effectiveness in producing an immune response.

The only smallpox vaccine licensed for use in the United States is made from unattenuated vaccinia virus and it has been associated with potentially fatal encephalitis and heart inflammation.

© 2005 United Press International, Inc. All Rights Reserved. Any reproduction, republication, redistribution and/or modification of any UPI content is expressly prohibited without UPI's prior written consent.
Most Popular
1
Next week's lunar eclipse may feature the color turquoise Next week's lunar eclipse may feature the color turquoise
2
35,000 walruses haul out of ocean, crowd Alaskan shore 35,000 walruses haul out of ocean, crowd Alaskan shore
3
NASA satellite shows scope of Aral Sea disaster NASA satellite shows scope of Aral Sea disaster
4
Apple releases fix for 'Shellshock' virus Apple releases fix for 'Shellshock' virus
5
Social network Ello getting thousands of requests per hour Social network Ello getting thousands of requests per hour
Trending News
x
Feedback