Strawberry, who famously struggled with alcohol and drug addiction during his playing career, will open the center in St. Cloud, Fla., and offer treatment to professional athletes and the general public.
The 51-year-old is now an ordained minister.
"A lot of athletes, we don't know [our purpose] when we're playing. We have the uniform on and we're stars and we play for this great team, but that's just what we do. A lot of us don't really know who we are," Strawberry said.
The former New York Met and New York Yankee was an eight-time All Star and a member of four world championship teams.
The Darryl Strawberry Recovery Center will house its guests together in a dorm-like setting.
"They could stay together and they can learn together and work together," Strawberry said.
The center will also serve as an outpatient clinic for people suffering from traumatic brain injuries.