Four people were arrested, the Boston Globe reported.
The stop occurred at about 3 a.m. north of Springfield in western Massachusetts, police said. A trooper allegedly observed several traffic violations, pulled the car over and discovered the driver did not have a license.
Evidence of drug use was also allegedly spotted, and the trooper requested a drug-sniffing dog, which led to the discovery of the heroin. State police said the heroin had red labels that said "Obama Care."
Tyler Robenstein, 23, and Ashley Beaulieu, 21, both of Colchester, Vt., and Marquese Jones, 22, and Sherod Green, 21, of Newark, N.J., were all charged with trafficking heroin and other drug charges. Robenstein, the driver, also faces several traffic charges.
Not guilty pleas were entered for all four at a court hearing Friday.