Charlotte Cates, owner of Wilderness Farm in Auburn, said the water buffalo broke through the door of her stall and wandered off, The Atlanta Journal-Constitution reported Monday.
"She was brand new and I had her in the stall," Cates said. "She busted through the door and I guess she got spooked or something."
The animal, which Cates said looks like a baby cow, was last seen Saturday night crossing Georgia 316 in both directions. Cates said storms likely frightened the water buffalo away from returning to her new home.
"She's really skittish," Cates said. "She doesn't come to you when you call her, that's for sure."
Cates said her biggest worry is motorists not noticing the animal crossing the street.
"That's the main thing I worry about is that someone's not going to see her in time," Cates said. "I want to get her back so badly."