Some in the group wore Guy Fawkes masks, popularized by the movie "V for Vendetta," Ahram Online reported Friday.
A video of the protest organized via Facebook was posted on YouTube.
President Mohamed Morsi, a longtime member of the Brotherhood, is a founder of the group's political arm, the Freedom and Justice Party. Members of the opposition have been increasingly critical of all three.
Recently, Brotherhood offices have been attacked by angry protesters. But there is also at least one earlier non-violent protest when activists held a soccer tournament in front of the group's office with a banner that read "Glory to the Martyrs."