Mike and Trina of St. Petersburg, who did not want their last name used, told ABC News the enemas take hours every day. Both work at home and they leave the house only for relatively short periods because they are unable to do without the daily ritual.
The couple will be featured on the first show of this season's "My Strange Addiction," which airs Feb. 13 on TLC.
Trina said she had been suffering from a variety of illnesses when she came across coffee enemas.
"I had a lot of stomach problems, digestive problems with my kidney and my liver," she said. "I started research and it led into coffee enemas and I really started to feel the benefit. I felt like I was living for the first time in years."
Dr. Roshini Rajapaksa, a gastroenterologist at NYU Medical Center, said coffee enemas have a "down side and really no upside." She said frequent enemas have no proven benefit but can cause irritation -- and there is always risk when a hose is inserted into the colon.