The contest, sponsored by the Florida Fish and Wildlife Conservation Commission, began Thursday, the South Florida Sun Sentinel reported.
So far, officials have not reported any dead snakes, but the contest runs through Feb. 10. The person who kills the most Burmese pythons by that date will receive a check for $1,500.
The Python Challenge was created to combat Florida's growing population of pythons that have devastated the state's rabbit, fox, possum and bobcat populations. Pythons are an invasive species in the United States.
A total of 777 people signed up for the contest.