The profile, which marks Michelle Obama's first foray into public social networking, had more than 153,000 followers as of Thursday afternoon.
"We're excited today to launch @michelleobama as a new way for you to connect with First Lady Michelle Obama and the President's campaign," the first tweet read, followed by, "Hi, everyone, and thanks for the warm welcome. Look forward to staying in touch with you here. -mo"
The first lady's staff said followers will know which tweets she writes personally by looking for her "-mo" signature.