Samantha Johnston, executive director of the Colorado Press Association, said the tiny reptile came through the faucet when she was getting some water for her office plants, The Denver Post reported Tuesday.
"He literally flopped out of there," Johnson said.
Stacy Chesney, spokeswoman for Denver Water, said it was unlikely the lizard traveled all the way through the city's water system, as the pressure would almost certainly have killed it and the system contains numerous screens to remove unwanted items.
"Checking in with my folks, this is definitely an unusual situation," she said. "We haven't had anything like this before. It's likely that it crawled in versus coming through."
Scales 'N Tails pet shop, where the lizard was taken, said the baby reptile maybe a fence lizard, which is native to the western United States but not often seen east of Utah.