The European eagle owl escaped Sunday from its enclosure in the back garden of a home in Lower Stratton, near Swindon, The Times of London Online reports.
"The owner went into the enclosure and the owl flew at him," says a spokeswoman for Wiltshire police.
The spokeswoman said the owl, which has a six-foot wingspan, is unlikely to attack humans because it was bred in captivity.
"But it could try to carry off a cat or small dog," she said. "If anyone spots the owl they should contact police and we will send an appropriate team."