Residents said signs are missing from the intersections of Bush and Kearny Streets, and Bush and Montgomery, the San Francisco Chronicle reported Thursday.
"I have helped numerous tourists (and locals) trying to find Bush Street (and Montgomery), but they had no idea where they were because there was no street sign," legal secretary Katherine Small said.
Officials said this is not the first time signs for Bush Street have been targeted.
"When the current president was first elected, we saw increased graffiti and vandalism on these particular street signs," San Francisco Municipal Transportation Agency spokesman Judson True said Wednesday. "It seems possible that these missing signs are also related to feelings about our current head of state."
True said the signs were scheduled to be replaced Thursday.