Brees, starting quarterback of the New Orleans Saints, told his mother, an attorney based in Austin, to discontinue the ads using his image, the Austin American-Statesman reported Tuesday.
The football player said his relationship with his mother had soured six years ago and was now "nonexistent."
"I think the major point here is that my mother is using me in a campaign, and I've made it known many times I don't want to be involved," Brees said.
He said he decided to make his demands public after his mother's campaign refused to heed earlier requests.
Mina Brees, a Democrat running against Republican Justice David Puryear, said replacement ads have been submitted to the TV stations running her spots.