Geovany Soto added a three-run inside-the-park homer for the Cubs, who have won five of their six last games. Mark DeRosa had two hits to extend his hit streak to 10 games and Ryan Theriot and Derrek Lee each had an RBI and scored a run.

Ted Lilly (5-4) won his fourth straight start, holding the Astros to two runs on four hits in 5 1/3 innings.

Michael Bourn and Carlos Lee each had two hits and an RBI for Houston, which has lost three of its last four games.

Lance Berkman's 17-game hit streak ended as he went 0-for-4 with three strikeouts. Hunter Pence's 16-game hit streak ended as he also was 0-for-4.

Brian Moehler (1-1) allowed three runs on seven hits in five innings.