The researchers want to recruit 400 cancer patients from the Merseyside and North Wales areas to complete a series of screening tests to detect signs of depression and demoralization. The scientists said depression affects one in four cancer patients, but it is largely unrecognized by clinicians and, therefore, often remains untreated.

The study, one of the largest of its kind ever conducted in the United Kingdom, will focus on establishing when and why some patients develop depression and also explore such issues as spirituality and personal beliefs.

The primary investigator, Professor Mari Lloyd-Williams, said the findings will be used to create improved palliative care regimes for patients with cancer and other long-term conditions.