facebook
twitter
rss
account
search
search
X
Breaking News: ISIS allegedly beheads second American journalist
 

Lilly voluntarily terminates Phase II trial for Alzheimer's drug

June 16, 2013 at 11:42 PM   |   Comments

INDIANAPOLIS, June 16 (UPI) -- U.S. drug maker Eli Lilly and Co. said it stopped its Phase II study of a promising drug to slow Alzheimer's disease over concerns about potential liver damage.

Jan M. Lundberg, executive vice president for science and technology and president of Lilly Research Laboratories, said the cases of abnormal liver biochemical tests were identified as part of routine monitoring. Lilly will continue to monitor all participants with abnormal liver biochemical tests, Lundberg said.

"While stopping this Phase II study for our beta secretase inhibitor is disappointing, patient safety is of utmost importance to Lilly," Lundberg said in a statement. "Discovering and developing medicines for devastating diseases like Alzheimer's is fraught with many challenges, but Lilly's 25-year commitment to bringing medicines to the millions of Alzheimer's disease patients who are waiting will not wane."

Lundberg said the abnormal liver biochemical tests observed in the study were not related to the beta secretase mechanism. The pharmaceutical giant said it is still interested in developing beta secretase inhibitors for the benefit of patients with Alzheimer's disease.

Lilly will further evaluate this data prior to determining next steps for the entire Phase II study beta secretase for LY2886721 clinical development program, Lundberg said.

The company expects to incur a financial charge associated with the decision to stop this trial. However, the amount of this charge is not expected to be material and is not expected to result in a change to the company's previously-issued 2013 financial guidance, Lilly said.

© 2013 United Press International, Inc. All Rights Reserved. Any reproduction, republication, redistribution and/or modification of any UPI content is expressly prohibited without UPI's prior written consent.
Recommended UPI Stories
Featured UPI Collection
trending
Notable deaths of 2014 [PHOTOS]

Notable deaths of 2014 [PHOTOS]

Most Popular
1
Cutting carbs, not fat, key to weight loss and heart health
2
Daughters more likely than sons to care for elder parents
3
India asks Pepsi to cut down on sugar in its soft drinks
4
Yoga guru BKS Iyengar dies at 95
5
NIH to test safety of Ebola vaccine candidate
Trending News
Video
x
Feedback