The report, published Thursday in the Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report, said more people died of suicide in the United States in 2010 -- 38,364 -- than died of motor vehicle crashes -- 33,687.
The researchers used data on U.S. adults ages 35-64 available through CDC's Web-based Injury Statistics Query and Reporting System from 1999-2010. Annual suicide rates for this age group increased 28 percent over the study period -- 13.7 suicides per 100,000 people in 1999 to 17.6 per 100,000 in 2010.
Increases in suicide rates among males and females were also observed from suicides involving hanging/suffocation, poisoning and firearms.
The suicide rates for those ages 10-34 and those age 65 and older did not change significantly during this period, the report said.
"Suicide is a tragedy that is far too common," Dr. Tom Frieden, director of the CDC, said in a statement. "This report highlights the need to expand our knowledge of risk factors so we can build on prevention programs that prevent suicide."
Suicide rates among those ages 35-64 increased 32 percent for women, 27 percent for men, with the greatest increases in suicide rates among those ages 50-54 at 48 percent and those ages 55-59 at 49 percent.