Su-Yang Liu, a student, and Genhong Cheng, a professor at the David Geffen School of Medicine at the University of California, Los Angeles, said the novel anti-viral property of the protein, cholesterol-25-hydroxylase, is an enzyme that converts cholesterol to an oxysterol called 25-hydroxycholesterol, which can permeate a cell's wall and block a virus from entering.
The cholesterol-25-hydroxylase enzyme is activated by interferon, an essential antiviral cell-signaling protein produced in the body, the researchers said.
"Anti-viral genes have been hard to apply for therapeutic purposes because it is difficult to express genes in cells," Liu said in a statement. "Cholesterol-25-hydroxylase produces a natural, soluble oxysterol that can be synthesized and administered. Also, our initial studies showing that 25HC can inhibit HIV growth in vivo should prompt further study into membrane-modifying cholesterols that inhibit viruses."
The discovery is particularly relevant to efforts to develop broad-spectrum antivirals against an increasing number of emerging viral pathogens, Liu said.
The findings were published in the journal Immunity.
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