facebook
twitter
rss
account
search
search
 

Vitamin D may be a breast cancer therapy

Jan. 22, 2013 at 11:08 PM   |   Comments

ST. LOUIS, Jan. 22 (UPI) -- Vitamin D may be involved in a possible new breast cancer therapy, U.S. and Spanish researchers say.

Susana Gonzalo, an assistant professor of biochemistry and molecular biology at Saint Louis University, and her team identified one pathway activated in breast cancers with the poorest prognosis, such as those classified as triple-negative. These cancers often strike younger women and are harder to treat than any other type of breast cancer.

Women who are born with BRCA1 gene mutations are at increased risk for developing breast and ovarian cancers, and the tumors that arise are frequently the triple-negative type. Although chemotherapy is the most effective treatment for triple-negative breast cancer, it has profound secondary effects, Gonzalo said.

Experiments performed in Gonzalo's laboratory, in collaboration with the laboratories of Xavier Matias-Guiu and Adriana Duso in Spain, showed activation of this novel pathway not only allowed tumor cells to grow unchecked, but also explains the reduced sensitivity of these types of tumors to current therapeutic strategies.

Importantly, vitamin D plays a role in turning off this pathway, providing a safe and cost-effective strategy to fight these types of tumors, Gonzalo said.

The findings were published in The Journal of Cell Biology.

© 2013 United Press International, Inc. All Rights Reserved. Any reproduction, republication, redistribution and/or modification of any UPI content is expressly prohibited without UPI's prior written consent.
Most Popular
1
Study: Early air pollution exposure linked to autism Study: Early air pollution exposure linked to autism
2
Family of Dallas nurse Amber Vinson says she's free of Ebola Family of Dallas nurse Amber Vinson says she's free of Ebola
3
Morning exercise helps calm ADHD symptoms in children Morning exercise helps calm ADHD symptoms in children
4
Yoga guru BKS Iyengar dies at 95 Yoga guru BKS Iyengar dies at 95
5
Michelle Obama made a 'Turn Down for What' Vine inspired by turnips Michelle Obama made a 'Turn Down for What' Vine inspired by turnips
Trending News
Around the Web
x
Feedback