Denise Head of the Washington University in St. Louis and colleagues looked at people with a form of the APOE gene -- AP0E-e4 -- which has been linked to greater buildup of amyloid protein in the brain.
Amyloids are proteins associated with the development of Alzheimer's disease.
"The combination of a sedentary lifestyle and APOE-e4 status was associated with a higher level of amyloid deposition," Head reported in the study, which was funded in part by the National Institutes of Health and published in the Archives of Neurology.
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