facebook
twitter
rss
account
search
search
 

Menopause onset may be genetic

Jan. 24, 2012 at 2:00 AM   |   Comments

BOSTON, Jan. 24 (UPI) -- Researchers from the Boston University Schools of Public Health and Medicine report they have found 13 genetic locations linked to the onset of menopause.

Menopause affects most women in their early 50s and most studies of the age of onset of menopause focused on genes from the estrogen-production pathway or vascular components.

The new study, published online in Nature Genetics, identified 13 novel locations associated with menopause onset, while confirming four previously established locations. Most are associated with genes related to DNA damage repair or auto-immune disease, while others are linked to hormonal regulation.

Kathryn Lunetta, a professor of biostatistics, and Joanne Murabito, an associate professor, examined more than 50,000 women of European descent who had experienced menopause from ages 40-60.

"We hope that as a better understanding of the biologic effects of these menopause-related variants are uncovered, we will gain new insights into the connections between menopause and cardiovascular disease, breast cancer, osteoporosis, and other traits related to aging and that this will provide avenues for prevention and treatment of these conditions," Lunetta said in a statement.

© 2012 United Press International, Inc. All Rights Reserved. Any reproduction, republication, redistribution and/or modification of any UPI content is expressly prohibited without UPI's prior written consent.
Recommended UPI Stories
Featured UPI Collection
trending
Celebrity Couples of 2014 [PHOTOS]

Celebrity Couples of 2014 [PHOTOS]

Most Popular
1
Fewer prescription pill overdoses in medical marijuana states
2
New data shows Melbourne is most well-rested city in the world
3
New research details rare cancer that killed Bob Marley
4
Daughters more likely than sons to care for elder parents
5
Poll: 26 percent of Americans believe they will get Ebola
Trending News
Video
x
Feedback