Diabetes drug fights inflammation

Nov. 2, 2011 at 10:57 PM
| License Photo

BUFFALO, N.Y., Nov. 2 (UPI) -- A drug prescribed to help patients with type 2 diabetes improve blood-sugar control also has a powerful anti-inflammatory effect, U.S. researchers say.

Dr. Paresh Dandona, a professor at the University at Buffalo School of Medicine and Biomedical Sciences, said the study of the drug exenatide, or Byetta, was designed after past observations indicated an anti-inflammatory effect, reducing plasma C-reactive protein levels, triglycerides and systolic blood pressure.

"Our most important finding was this rapid, anti-inflammatory effect, which may lead to the inhibition of atherosclerosis, the major cause of heart attacks, strokes and gangrene in diabetics," Dandona, the senior author, said in a statement.

It was noteworthy the anti-inflammatory effect occurred independently of weight loss over the 12-week study period, Dandona said.

Dr. Ajay Chaudhuri said obesity is an inflammatory state and adipose tissue contributes to inflammation. If a person loses weight it can lead to an anti-inflammatory effect.

"The fact that the drug caused this dramatic and comprehensive anti-inflammatory effect independent of weight loss shows that it is a primary action of the drug and is not dependent upon weight loss," Chaudhuri, the lead author, said. "Even more importantly, a short-lived anti-inflammatory effect was observed within 2 hours following a single injection of 5 micrograms of the drug. This coincides with the peak concentration of the drug after the injection. Such a rapid and dramatic effect is rare."

The study was published recently in the Journal of Clinical Endocrinology and Metabolism.

Related UPI Stories
Latest Headlines
Trending Stories
House Majority Leader Kevin McCarthy drops bid for speaker
WikiLeaks offering $50K for video of Afghan hospital bombing
Murdoch sorry for implying Obama's not a 'real black president'
Reid sues exercise companies over eye injury
Lumber Liquidators to pay $10M in DOJ settlement