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Prostate history need not change therapy

MIAMI, Oct. 5 (UPI) -- Men with a family history of prostate cancer should expect as good outcomes following radiation as patients who don't, U.S. researchers say.

Dr. Mark Buyyounouski, a radiation oncologist at Fox Chase Cancer Center in Philadelphia, and colleagues examined 1,711 men who received three-dimensional conformal (3DCRT) or intensity modulated radiotherapy from 1989 to 2007 at Fox Chase Cancer Center.

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A positive family history was defined as any prostate cancer in one or more first-degree relatives. In the study, 28 percent of the patients had a positive family history for prostate cancer. The median follow-up from completion of treatment was 71 months, Buyyounouski said.

"What we learned was that whether the men had a history of prostate cancer or not, all had equivalent prostate specific antigen controls, freedom from metastasis or cancer spread, recurrence-free survival and overall survival," Buyyounouski said in a statement.

"Patients should feel comfortable knowing that when they receive radiotherapy having a history of prostate cancer in the family doesn't compromise the results. This is important because patients, especially those with a family history, might assume that radiotherapy might not work as well and opt for surgery when it may not be necessary."

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Buyyounouski presented the findings at the 53rd annual meeting of the American Society of Radiation Oncology in Miami.

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