Kim Janda of the Scripps Research Institute in La Jolla, Calif., and colleagues note methamphetamine use and addiction cost the United States more than $23 billion annually due to medical and law enforcement expenses, as well as lost productivity.
The highly addictive crystal meth can cause a variety of problems including cardiovascular damage and death.
The study, published in the Journal of the American Chemical Society, found three of the new formulations that produced a good immune response in mice were particularly promising.
These findings represent a unique approach to the design of new vaccines against methamphetamine abuse, Janda says.
Previously tested meth vaccines either are not effective or are very expensive.