Obesity gene may up dementia risk

Feb. 21, 2011 at 10:19 PM   |   Comments

STOCKHOLM, Sweden, Feb. 21 (UPI) -- People with the FTO genotype linked to overweight and increased diabetes risk have three times the risk for Alzheimer's disease, researchers in Sweden say.

Study leader Caroline Graff of the Karolinska Institute in Stockholm says the study subjects with the genotype were not necessarily obese during the study, but they may have been previously overweight.

"In a way, the finding that surprises us most is that when we correct for body mass index, we still see the effect. We thought the effect would work through a higher BMI," Graff told The Local.

"One explanation may be that those we examined were already way into the disease. That could explain why their BMI was already lower, but we don't know whether this effect is independent of BMI or not."

The study involved 1,003 individuals age 75 and older -- half who had the FTO genotype -- who did not have or had not yet been diagnosed with dementia at the beginning of the study.

The findings are published in the Journal of Alzheimer's Disease.

© 2011 United Press International, Inc. All Rights Reserved. Any reproduction, republication, redistribution and/or modification of any UPI content is expressly prohibited without UPI's prior written consent.
Recommended UPI Stories
Most Popular
Human brain can be trained to prefer healthy foods
Cutting carbs, not fat, key to weight loss and heart health
Daughters more likely than sons to care for elder parents
India asks Pepsi to cut down on sugar in its soft drinks
Yoga guru BKS Iyengar dies at 95
Trending News