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MILWAUKEE, Feb. 16 (UPI) -- Early signs of cardiovascular disease are likely to manifest before the onset of puberty in many children with type 1 diabetes, U.S. researchers say.
Study leader Dr. Ramin Alemzadeh of the Children's Hospital of Wisconsin, senior clinician scientist at Children's Hospital's Max McGee Juvenile Diabetes Research Center, and colleagues studied 21 preadolescent children -- average age 8.5 -- with type 1 diabetes and compared them to15 healthy siblings.
Investigators looked at flow-mediated dilatation -- a gauge of the health of a major blood vessel of the upper arm artery by measuring any stiffening of the blood vessels an early sign of heart disease.
The blood vessels of children with type 1 diabetes had a lower flow-mediated dilatation change, which means their blood vessels were less expandable than those of the control group, suggesting higher circulating glucose results in increased rigidity of blood vessels independent of cholesterol levels.
The patients with diabetes also had vascular inflammation, which is a known harbinger of future cardiovascular risk, Alemzadeh adds.
The findings are published online ahead of print of the March issue of Diabetes Care.
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