

BOSTON, Feb. 15 (UPI) -- Cigarette smoking may be associated with an increased risk of amyotrophic lateral sclerosis, also known as Lou Gehrig's disease, U.S. researchers say.
Dr. Hao Wang of the Harvard School of Public Health in Boston and colleagues analyzed five long-term studies involving more than 1.1 million participants, of whom 832 had ALS. The follow-up among the studies ranged from seven to 28 years.
The rates of ALS in the five studies combined increased with age and were higher in men than women for all age groups.
The review, published in the issue of Archives of Neurology, found those who had smoked cigarettes at some time at the beginning of the study had an increased risk of ALS compared with those who had never smoked. In addition, current smokers had a 42 percent increased risk of developing the disease and former smokers had a 44 percent increased risk, the study says.
The risk of developing ALS also increased with the number of pack-years smoked, the study says.
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