Combining cancer therapies may create risk

Feb. 2, 2011 at 8:57 PM   |   Comments

STONY BROOK, N.Y., Feb. 2 (UPI) -- Combining a commonly-prescribed cancer drug with chemotherapy may increase the risk of death, a U.S. study suggests.

Researchers at Stony Brook University Medical Center in New York say studies show the cancer drug bevacizumab, sold under the trade name Avastin, coupled with chemotherapy can increase the risk of treatment-related death, medicalnewstoday.com reported Wednesday.

Stony Brook's Vishal Ranpura conducted a review of studies in which bevacizumab in combination with chemotherapy or biological therapy was compared with chemotherapy or biological therapy alone.

Compared with chemotherapy alone, the addition of bevacizumab was associated with a 1.5-times increased risk of fatal adverse events, he found.

Bevacizumab was associated with a 3.5-times increased risk of FAEs in patients receiving biological therapies involving taxanes or platinum agents.

Bevacizumab is currently approved by the U.S. Food and Drug Administration for cancers that are metastatic and have spread to other parts of the body.

"Even though a number of FAEs (fatal adverse events) have been reported in patients treated with bevacizumab, its role in the development of these fatal events has not been definitively established," the American Medical Association said in an article in its journal. "Data across bevacizumab trials reveal conflicting results regarding its associations with FAEs."

© 2011 United Press International, Inc. All Rights Reserved. Any reproduction, republication, redistribution and/or modification of any UPI content is expressly prohibited without UPI's prior written consent.
Recommended UPI Stories
Most Popular
Child vaccination rates are high, CDC says
Daughters more likely than sons to care for elder parents
India asks Pepsi to cut down on sugar in its soft drinks
Yoga guru BKS Iyengar dies at 95
NIH to test safety of Ebola vaccine candidate
Trending News