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Celastrol: Plant compound may treat cancer

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Published: Feb. 5, 2010 at 2:53 PM

ATLANTA, Feb. 5 (UPI) -- U.S. researchers say a plant long used in Chinese medicine may become a cancer treatment.

The researchers at the Medical College of Georgia in Atlanta say they are seeking to refine the treatment of cancer with the anti-inflammatory plant derivative -- celastrol-- taken from trees and shrubs called celastracaea.

The study, published in The Journal of Biological Chemistry, found celastrol may help treat cancer by inactivating a protein required for cancer growth.

"The celastrol induces the protein to form fibrils and clusters it together, which inactivates it," researcher Ahmed Chadli said in a statement. "When they are clustered, they're not available for other functions that help cancer grow."

Chadli envisions celastrol being used in combination with other therapeutic agents to help patients resist cancer.

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