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Vitamin D may fight Crohn's disease

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Published: Jan. 30, 2010 at 12:40 AM

MONTREAL, Jan. 30 (UPI) -- Canadian researchers say vitamin D can counter the effects of Crohn's disease.

Researchers at Montreal's McGill University Health Center and University of Montreal found vitamin D acts directly on the beta defensin 2 gene, which encodes an anti-microbial peptide and the NOD2 gene that alerts cells to the presence of invading microbes.

Both Beta-defensin and NOD2 have been linked to Crohn's disease -- an autoimmune disorder in which a defect in innate immune handling of intestinal bacteria leads to inflammatory bowel disease.

"Our data suggests, for the first time, that vitamin D deficiency can contribute to Crohn's disease," study leader Dr. John White of McGill says in a statement.

White suggests siblings of patients with Crohn's disease who have not as yet developed the disease make sure they are vitamin D sufficient.

"It's something that's easy to do, because they can simply go to a pharmacy and buy vitamin D supplements," he says.

The study findings are published in the Journal of Biological Chemistry.

© 2010 United Press International, Inc. All Rights Reserved. Any reproduction, republication, redistribution and/or modification of any UPI content is expressly prohibited without UPI's prior written consent.

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