Newly found molecule disrupts cancer cells

PHILADELPHIA, Nov. 5 (UPI) -- U.S. scientists say they have discovered a small molecule that inhibits the actions of a protein cancer cells require for survival.

The researchers said they determined the molecule, called PES, inhibits a type of protein called a heat-shock protein that helps cells survive heat, lack of nutrients and other cell-damaging conditions.

Assistant Professors Donna George and Julie Leu of the University of Pennsylvania, along with Maureen Murphy of the Fox Chase Cancer Center, said they found the molecule inhibits a heat shock protein that many cancer cells use to repair damage and survive. PES disrupted the cancer cell's ability to rid itself of damaged components and, as a result, PES halted tumor formation and significantly extended the survival of mice.

Murphy said the molecule was equally effective in every type of cancer cell tested.

That, she said, "is unusual and supports the idea that it is targeting a protein that is required for the functioning of multiple pathways."

The scientists said they expect their findings to lead to development of anti-cancer treatments.

The research appears in the journal Molecular Cell.