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Negative H1N1 test may not be negative

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President Barack Obama speaks on the H1N1 flu virus after receiving a briefing at White House in Washington on September 1, 2009. Obama was joined by from left to right, White House Homeland Security Advisor John Brennan, Education Secretary Arne Duncan, Health and Human Services Secretary Kathleen, Homeland Security Secretary Janet Napolitano, Commerce Secretary, Commerce Secretary Gary Locke and Centers for Disease Control and Prevention Director Tom Frieden. UPI/Kevin Dietsch 
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Published: Sept. 24, 2009 at 1:36 PM

ATLANTA, Sept. 24 (UPI) -- A positive rapid test for influenza is helpful, but a negative result does not rule out pandemic influenza A H1N1 infection, U.S. health officials said.

The Centers for Disease Control and Prevention's Mortality and Morbidity Weekly Report said Thursday two school outbreaks of pandemic influenza diagnosed last May at Greenwich Hospital in Connecticut afforded an opportunity to examine the performance of a rapid diagnostic test in detecting the pandemic virus formally called swine flu.

Dr. James R. Sabetta of the Greenwich Department of Health and the Connecticut Department of Public Health compared the results from rapid tests with the reverse transcriptase -- polymerase chain reaction assay.

A low sensitivity of 47 percent was found for the rapid test. The performance could not be explained by the clinical features of the patients or by the timing of the specimen collection, the report said.

The results affirm recent CDC recommendations not to use negative rapid test results for the management of patients with possible pandemic influenza A H1N1 infection, health officials said.

Topics: H1N1
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