Nicotine addiction and autism linked

WASHINGTON, Nov. 17 (UPI) -- U.S. scientists say they have identified a relationship between two brain proteins with links to both nicotine addiction and autism.

Principal investigator Rene Anand of Ohio State University's College of Medicine said the finding has led to speculation that existing drugs used to curb nicotine addiction might serve as the basis for potential therapies to alleviate the symptoms of autism.

The researchers identified a protein made by the neurexin-1 gene, which is located in brain cells and assists in connecting neurons as part of the brain's chemical communication system. The neurexin-1 beta protein's job is to lure another protein, a specific type of nicotinic acetylcholine receptor, to the synapses, where the receptor then has a role in helping neurons communicate signals among themselves and to the rest of the body.

This function is important in autism because previous research has shown that people with autism have a shortage of these nicotinic receptors in their brains. Scientists also know that people who are addicted to nicotine have too many of these receptors in their brains.

Anand presented the research at the Society for Neuroscience meeting in Washington.