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Leukemia drug effective against MS

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Published: Oct. 23, 2008 at 3:41 PM

CAMBRIDGE, England, Oct. 23 (UPI) -- A drug initially designed to treat a form of leukemia has also proven effective against multiple sclerosis, British researchers said.

Researchers led by the University of Cambridge found that the drug alemtuzumab not only stops MS from advancing in patients with early stage active relapsing-remitting multiple sclerosis, or RRMS, but may also restore lost function caused by the disease.

The study found alemtuzumab reduces the number of attacks experienced by people with relapsing-remitting multiple sclerosis by 74 percent over and above that achieved with interferon beta-1a, one of the most effective licensed therapies for similar cases of MS.

However, alemtuzumab also reduced the risk of sustained accumulation of disability by 71 percent compared to interferon beta-1a.

Additionally, the investigators showed that many individuals in the trial who received alemtuzumab recovered some lost function and were less disabled after three years than at the beginning of the study, in contrast to worsening disability in the interferon beta-1a treated patients.

The findings are published in the New England Journal of Medicine.

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