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New collagen 'un-ages' skin

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Published: May 29, 2008 at 11:53 PM

ANN ARBOR, Mich., May 29 (UPI) -- U.S. scientists say it might be possible to counteract the skin breakdown causing wrinkles, sags and even bed sores.

University of Michigan researchers found three existing treatments -- topical retinoic acid, carbon dioxide laser resurfacing and injections of cross-linked hyaluronic acid -- improved the skin's appearance and its ability to resist bruises and tears because these treatments were able to stimulate the growth of new collagen.

Collagen is made up of proteins and forms the supporting sub-surface of the inner skin known as the dermis. It is formed by cells called fibroblasts. When the fibroblasts produce collagen the dermis is thicker and the outer thin layer of skin known as the epidermis appears taut and youthful much in the same way a sheet lies smoothly on a firm mattress.

"We have shown that if you make more collagen go in, it provides an environment in which fibroblasts recover and make more collagen," senior study author Dr. John Voorhees said in a statement.

The study findings are published in the Archives of Dermatology.

© 2008 United Press International, Inc. All Rights Reserved. Any reproduction, republication, redistribution and/or modification of any UPI content is expressly prohibited without UPI's prior written consent.

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