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Reducing blood flow after stroke helpful

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Published: Dec. 29, 2006 at 11:21 AM

SAN FRANCISCO, Dec. 29 (UPI) -- Researchers at the San Francisco VA Medical Center say a novel treatment -- reducing blood flow -- may help prevent brain damage caused by stroke.

In the study, rats' brains were subjected to ischemia -- severely reduced blood flow -- for two hours in a model of stroke. Researchers then administered nicotinamide adenine dinucleotide immediately after "reperfusion," or resumption of blood flow. Reperfusion is the time when stroke damage actually occurs because brain cells are suddenly exposed to highly reactive and unstable oxygen molecules, which are toxic, according to lead author Weihei Ying of the San Francisco VA Medical Center and the University of California-San Francisco.

The researchers found that those given the nicotinamide adenine dinucleotide had reduced brain cell death from reperfusion by 70 percent to 86 percent compared with rats not given the treatment, according to the study published in the journal Frontiers in Bioscience.

"Basically, we replenish the nicotinamide adenine dinucleotide," Ying explains. "The protective effect is profound."

© 2006 United Press International, Inc. All Rights Reserved. Any reproduction, republication, redistribution and/or modification of any UPI content is expressly prohibited without UPI's prior written consent.

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