facebook
twitter
rss
account
search
search
 

T-cells from stem cells could help AIDS

July 3, 2006 at 8:25 PM   |   Comments

WASHINGTON, July 3 (UPI) -- Mature T-cells have been developed for the first time from human embryonic stem cells, and the U.S. researchers involved hope a new AIDS therapy will follow.

T-cells are key components in the immune system and lead the body's fight against infection. The AIDS virus destroys T-cells, and people with AIDS typically die from unusual infections people with healthy immune systems do not get, such as pneumocystis pneumonia.

The work was done at the UCLA AIDS Institute and the Institute for Stem Cell Biology and Medicine, where scientists led by Zoran Galic and Jerome Zack incubated human embryonic stem cells on mouse bone marrow support cells.

The researchers explained that stem cells are blank slates that decide how they will mature based on the biological environment in which they find themselves. The mouse bone marrow encouraged the human stem cells to develop into blood-forming (hematopoietic) cells. The new hematopoietic cells were then injected into a human thymus gland implanted in a mouse, and the thymus gland (where T-cells develop) changed them into T-cells.

The team hopes their process will lead to new therapies for AIDS and other T-cell diseases, such as severe combined immunodeficiency syndrome or "bubble boy disease." The study is online at http://www.pnas.org/papbyrecent.shtml.

© 2006 United Press International, Inc. All Rights Reserved. Any reproduction, republication, redistribution and/or modification of any UPI content is expressly prohibited without UPI's prior written consent.
Recommended UPI Stories
Featured UPI Collection
trending
Notable deaths of 2014 [PHOTOS]

Notable deaths of 2014 [PHOTOS]

Most Popular
1
Schizophrenia is actually eight disorders, not one disease Schizophrenia is actually eight disorders, not one disease
2
Study: too many kids taking antibiotics Study: too many kids taking antibiotics
3
Morning exercise helps calm ADHD symptoms in children Morning exercise helps calm ADHD symptoms in children
4
CDC: painkiller overdose deaths still rising, but not as fast CDC: painkiller overdose deaths still rising, but not as fast
5
Yoga guru BKS Iyengar dies at 95 Yoga guru BKS Iyengar dies at 95
Trending News
Video
x
Feedback