It all began when Chelsea Handler told the 51-year-old actress that she likes the answer she gave a paparazzo when asked about the secret behind her youthful look.
"[I said] Semen," Locklear said smiling. "Which isn't true! Well, I mean I think it might be true somewhere."
Handler then jumped in and pointed out that news of Locklear's use of semen as a beauty product is all over the Internet, adding, "By the way, there are products that have semen in them -- and I'm, like, why would I need to buy that?"
Earlier in the interview Handler asked Locklear what she truly did to look so "amazing."
"What's the story with that? she asked. "How do you keep that going?"
"Weights!" the actress confessed. "Stupid, boring weights."