The small-screen adaptation of Brian McGreevy's novel was created by Eli Roth.
Season 2 starred Famke Janssen, Bill Skarsgard, Landon Liboiron, Dougray Scott and Madeleine Martin.
Showrunner Charles H. Eglee will return for the 10-episode final season.
"We are so grateful to the fans of Hemlock Grove who have championed the series so intensely over two seasons," Roth said in a statement. "We are looking forward to taking the last and final season into some dark and unexpected places, and to giving viewers the killer finale you'd come to expect from Hemlock Grove."
"We are delighted that our fans have invited us back to explore the fiendish recesses of the human condition for another season. Knowing it will be our last gives us the opportunity to go out in a mushroom cloud of clever and soul-shattering mayhem. See you soon on the twisted streets of Hemlock Grove," added Eglee.
"We, along with the fans, are looking forward to visiting Hemlock Grove one last time, and we know that Chic, Eli and the team will provide a riveting and mind-bending conclusion to complete the series," said Cindy Holland, Netflix's vice president of original programming.