Also booked for the one-hour broadcast are Pierce Brosnan, Halle Berry, Kiefer Sutherland, Dane Cook, Jon Hamm, Ben Stiller, Will Ferrell, Mark Harmon, Rob Lowe, Jesse Tyler Ferguson, Eric Stonestreet, Danny McBride and Kareem Abdul-Jabbar.
The event is to air simultaneously on ABC, CBS, Fox and NBC, along with ABC Family, American Forces Network, Bravo, Cooking Channel, Discovery Fit & Health, E!, Encore, Encore Espanol, EPIX, ESPNEWS, Fox Sports 2, FXM, HBO, HBO Latino, ION Television, LMN, Logo TV, MLB Network, National Geographic Channel, Oxygen, Palladia, Pivot, Showtime, Smithsonian Channel, Starz, TNT and VH1. The show also will stream live on Hulu and Yahoo.
The telethon's traditional celebrity-staffed phone bank will be replaced by a digital lounge, producers said.
"Since we started Stand Up to Cancer in 2008, social media has exploded, creating a whole new way to connect," Katie Couric, a Stand Up to Cancer co-founder, said in a statement Wednesday. "So in an unprecedented way, we'll have plenty of stars reaching out to donors via social media, thanking them through Facebook messages, digital shout-outs, Instagrams and tweets. In other words, this year, we are so 2014!"