Christopher Knight, Mike Lookinland, Susan Olsen and Barry Williams will appear live on Thursday's edition of the program, while their former co-stars Ann B. Davis and Eve Plumb are set to deliver special videotaped birthday messages.
Maureen McCormick, the only other surviving member of the cast, will not be participating, but the network didn't say why.
Co-star Robert Reed died of colon cancer at age 59 in 1992.
"Cast members will share fun behind-the-scenes tales from their days on 'The Brady Bunch' set, reminisce about favorite memories and episodes, and share personal stories about their television mom," CBS said in a news release about Thursday's episode of "The Talk."
"Chef Jason Santos will prepare the classic Brady dish -- pork chops and applesauce -- in a homage to the memorable episode in which Peter Brady impersonates Humphrey Bogart saying, 'Pork chops and applesauce... isn't that swell!'"
"The Brady Bunch," which premiered 44 years ago, revolved around a large blended family with six children. The show ran until March 8, 1974, and remains popular in reruns.