The announcement was made by David Nevins, the cable network's president of entertainment.
The show stars David Duchovny, Natascha McElhone, Madeleine Martin, Evan Handler and Pamela Adlon.
"With its unique blend of lyricism and excess, 'Californication' has been one of our groundbreaking signature series," said Nevins in a statement. "We will always be indebted to Tom Kapinos for leading the creative charge on this memorable comedy, and to David Duchovny for making us root for an unapologetic hedonist like Hank Moody. Tom has carefully planned the final chapter of Hank's journey and has brought it to a beautiful and satisfying conclusion for new and long-time fans alike."