The show will wrap up its initial run at the Oregon Museum of Science and Industry Jan. 5.
"The brand-new, interactive experience combines science with history and culture to bring to life the historic underpinnings of author Sir Arthur Conan Doyle's rich and vibrant stories," the science center said in a release.
Visitors to the exhibition will learn how Holmes would have used the power of observation to solve crimes in 19th century England. They will also be invited to view some of Doyle's original manuscripts, as well as period artifacts and investigative tools.
"COSI is excited to be the second host of this one-of-a-kind exhibition building on the compelling deductive reasoning of the favorite character, Sherlock Holmes," David Chesebrough, the science center's president and chief executive officer, said in a statement. "Guests will be able to immerse themselves into the world of Sherlock Holmes at 221B Baker Street and solve an apparent crime using the deductive thinking Holmes is known for."
"The Conan Doyle estate can't remember an undertaking as involved and exciting as this one," said the estate's U.S. representative, Jon Lellenberg. "Museum visitors will experience the scientific and literary ideas that inspired Sir Arthur Conan Doyle to create Sherlock Holmes, and Holmes' methods for investigating and solving crimes as the world's first consulting detective, and they will visit their two worlds, including the very rooms in which all this took place."
Set to run through Sept. 1, the exhibition is to take place during a revival of interest in Holmes, which has been fired by the TV mystery drama series "Elementary" and "Sherlock," both of which are contemporary shows about the detective. Robert Downey Jr. has also played Holmes in two recent films set in the original Victorian London.