Dina, 48, cited irreconcilable differences as the reason for the split from Clint, 83, in new papers she filed Tuesday.
She requested full physical custody of their 16-year-old daughter, Morgan, as well as spousal support and attorneys' fees.
The couple married in 1996 and stopped living together last year.
Clint has seven other children from previous relationships and reportedly has a new girlfriend, Erica Tomlinson-Fisher.
Notable deaths of 2014 [PHOTOS]
'7th Heaven' cast reunites for family dinner