The couple were seen holding hands and kissing as they walked the red carpet together at Tuesday's event at the Academy of Motion Picture Arts & Sciences, the report said.
It was unclear how long the two have been an item.
Drescher, 59, is best known for her work on the TV sitcoms "The Nanny" and "Happily Divorced."
Ayyadurai, 49, holds the copyright to the computer program known as "EMAIL."
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