"She underwent a radical hysterectomy today," Grammer's representative Howard Bragman told People.com Friday. "The surgery went well and she is expected to make a complete recovery following a significant recuperation period."
Bragman said Grammer was at an elevated risk for cancer due to genetic issues.
"[She] has been diligent about regular checkups and monitoring, which explains the early detection and rapid treatment," the publicist said.
"Ms. Grammer expresses gratitude to all the amazing health care professionals who have taken such loving and nurturing care of her. She urges all women to be aware of genetic factors relating to women's cancers and get regular checkups."
Grammer, 45, is a former cast member of "Real Housewives of Beverly Hills." She has two children via surrogate with her ex-husband, actor Kelsey Grammer.
'SNL': 'Anchorman 2' cast, One Direction sing 'Afternoon Delight' [VIDEO]
Trader Joe's: Car crashes into Long Island store, injuring 11