"We are living separately and we are much happier this way," the Jenners told E! News in a joint statement. "But we will always have much love and respect for each other. Even though we are separated, we will always remain best friends and, as always, our family will remain our No. 1 priority."
The pair did not say whether they plan to divorce.
Kris has four adult children -- Kourtney, Kim, Khloe and Robert Kardashian -- with her late ex-husband, lawyer Robert Kardashian.
Kris has been married to Bruce Jenner since 1991. They have two teen-age daughters -- Kendall and Kylie.