Louis-Dreyfus picked up the statuette for Outstanding Lead Actress in a Comedy Series. Hale took home the prize for Outstanding Supporting Actor in a Comedy Series.
"I'm very grateful to have the opportunity to make people laugh. It's a joyful way to make a living," Louis-Dreyfus said as she collected her career fourth Emmy. She previously starred on "Seinfeld" and "The New Adventures of Old Christine."
Jim Parsons won the award for Outstanding Lead Actor in a Comedy Series for his work in "The Big Bang Theory."
"Boy, I want you to know that I'm very aware of how exceedingly fortunate I am," Parsons said as he accepted his award.