Jonas will portray a computer hacker involved in a case the Five-0 team is investigating and whose motives might be more complicated than the detectives suspect, the network said in a news release.
"Nothing makes this show more fun than incorporating well-known, talented actors as guest stars on our show," Executive Producer Peter Lenkov said in a statement.
"We're all thrilled to have Nick Jonas join our Ohana," Lenkov said, referring to the Hawaiian word for "family."
In addition to performing with his siblings as The Jonas Brothers, Nick Jonas has starred in the Broadway musicals "Les Miserables," "Beauty and the Beast," "Annie Get Your Gun," "A Christmas Carol" and "How to Succeed in Business without Really Trying." Jonas' television credits include "Mr. Sunshine," "Last Man Standing" and "Smash."
Season 4 of "Hawaii Five-0" is to premiere Sept. 27.