The iconic supernatural show made its debut in 2004 and wrapped its six-season run in 2010.
"Ten years does seem like the perfect time," Lindelof told E! News about the possibility the show's stars might reunite at the popular fan convention next year.
"But I also wonder if it's too soon? Especially if the announcement of such a panel would stir up rumors of more 'Lost,' which is most definitely not in the cards at this time. That said, if someone was organizing it, I would be foolish not to attend ... It's just not anything we've initiated internally."