The show stars Alley as Madison, as a Broadway star whose 26-year-old biological son tries to reconnect with her after his adoptive mother dies.
Perlman plays Thelma, Madison's assistant and best friend, while Wendt will guest star as Thelma's ex-husband, Duke Bainbridge, a professional pool player who cheated on Thelma while they were married, The Hollywood Reporter said Friday.
In addition to a "Cheers" reunion, the show will reconnect members of the Seinfeld cast.
A premiere date for the series has not yet been determined.
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